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> The Usona Phase 2 trial plans to enrol 80 subjects, randomized to receive either a single active dose of psilocybin or an active placebo containing niacin.

Blind testing in this case seems silly. It’ll be obvious to both patient and doctor pretty quickly who got the high dose psychedelic and who got placebo

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Always good to make sure, especially in psychology where placebo effects can be really really strong, especially if you're talking about microdosing psiliocybin. There's no reason not to be scientifically thorough and make sure you have a good control group to compare against

It's never silly! What if there's a chance the same effect can be recreated just by the setting and not the drug? Seems nearly impossible but I'd rather have control.

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