My keyboard is an ErgoDox EZ with the lightest key-switches I could find (bought them separate, soldered them on), and my mouse is placed in the middle. I'm happy with other keyboards though, my general keyboard requirements are:
* ortholinear
* as many modifier keys on the inside as possible (eg CTRL/SUPER/SHIFT for pointer and thumb, instead of using pinky)
* split layout
I use a 3M adjustable keyboard tray (atk91le) screwed into my desk so I can easily adjust position for whatever posture I'm in.
If you sit too long without moving you will hurt, so I make a point to switch up how I sit, or get up from my desk frequently. I really like the footstool as a chair because it's like an elevated floor, there are many ways to sit on it.
If my lower back is tired (no backrest on a footstool), I have a Nada Chair that I'll sometimes strap into.
I have scoliosis, so I think I've had to deal with lower back pain much more than the average person my age.