It depends. You could optimize for having a chill life as one of your top priorities. I think the advice is about consciously and explicitly managing the tradeoffs of your choices.

Chase the extreme pleasures by experiencing much pain.

Or be an Epicurean and enjoy the neutral state most, pleasures but not at the expense of pain.

Or be a Stoic and find comfort in realizing you aren't invading Russia in the winter.

I'd agree. I've seen people who try to min-max their life and "fulfilled" is not a word I'd use to describe them.