Being laid off puts kind of a stink on you, even if slight, that requires a bit of interview time be spent clarifying WHY you got laid off instead of entirely being able to focus on experience, accomplishments etc. When I was moving from one place to another, there seemed to be a noticeable sense of urgency on the new company's part to recruit me away.
However, as long as you get your story straight I think it’s easier to explain a stretch of unemployment more now than it used to be. I can appreciate that I'm probably saying this from a place of privilege working in tech-orbit. I bet my tone changes if I suffer a layoff in my older age.