"SameSite" affects sending the cookie in situations where top-level site in the browser context is different from the target site of the request where the browser is determining if it should send cookies. e.g. on example.site with an iframe to widget.site
"Domain" determine the the highest level domain to which cookies should be sent, regardless of the browsing context. e.g. on example.site an iframe on widgets.example.site or top-level navigation to accounts.example.site
https://developer.mozilla.org/en-US/docs/Web/HTTP/Headers/Se... details: > * If omitted, defaults to the host of the current document URL, not including subdomains. > * If a domain is specified, subdomains are always included.