In first world European cases, though, I think it's much less about independence and far more about being a top level subdivision of a country. Catalan, Flanders, Scotland etc want to become member-states in the EU with a seat at that table. They're after a seat at the table that decides the rules that govern them, and want to be able to defend their own interests. This is, after all, the point of a federation, so it's a natural thing to want: If it weren't a valid desire, the heads of government of the member states would not have a role in the EU. It's fairly common for territories to be cut up and distinct parts removed once they join a federation, especially when they're at least as large and diverse as Europe (take a squizz at India's states).