> They might cause some significant harm to their sanity.

Is that possible?

The drug counselor at my college, when asked by someone in the audience at a presentation he was giving about drug history, which drug would be the least harmful to use if someone wanted to, said immediately, "LSD."

A collective gasp was let out by the crowd, especially considering he'd just said earlier it would take smoking 15 pounds of marijuana in 30 minutes to OD on it. That seemed pretty darn safe.