I learned a lot by watching this and I highly recommend it but the viewer should be warned that many of the tools and techniques seem to have fallen out of favor in the Django community.

In my personal experience nginx+gunicorn turned out to be much easier to deal with than the reference Apache+mod_wsgi. It also seems to be JKM's current preference. Likewise, buildout, while very powerful can be a bit burdensome, and has fallen out of favor relative to pip+virtualenv.

For more current info, check out this extended chat with JKM and other lead Django developers here:

[discuss] http://news.ycombinator.com/item?id=2112160 [direct] http://www.revsys.com/officehours/2010/nov/05/

Note: This video is a dup to http://news.ycombinator.com/item?id=1830696 though I'm surprised that post only got one point. There are probably others.