Yes, and the problem is not JavaScript performance per se. The problem is slowness in the canvas implementation in several browsers.

In my game 90%+ is spend drawing to canvas.

In some cases its better to use the DOM to render the game, especially if the platform has accelerated CSS3 transform and translate3d (like iOS).

What I did was to abstract the drawing so the game can render either to canvas or DOM depending on what is faster for the platform the code runs on.