Not using chemical rockets. Nuclear propulsion would be able to do it with the ~1000000x energy density advantage of nuclear fuel over chemical fuel.
I can't find the video I saw, but here's a general link on the topic:
https://en.wikipedia.org/wiki/Laser_propulsion#Laser_energiz...
This comes with many problems, but it does bypass the rocket equation, while not requiring Project Orion levels of trouble.
Imagine how hard space exploration would be if the only practical rocket were a Project Orion.