Frequent long-term use of any stimulant is probably not great for you; e.g. my mother has a pretty severe coffee addiction (she typically drinks 4–8 cups per day), and gets headaches and shakes if she goes a couple days without. But compared to other kinds of drugs, it doesn’t seem like such a huge public health threat that we should freak out about it.
https://www.gwern.net/Nicotine#addictiveness.
Apparently in most popular, educational and health-related communication, nicotine is treated as synonym to tobacco, leading to confusion.
I know what I would do if I was selling drugs and didn't give a crap about anything but profits, I would make them as addictive as possible.
I've only tried sun-dried leaves from my own garden yet, which isn't quite as exciting. The nicotine boost is still the same though.
The idea is to grow enough to make my own mapacho paste and ferment a roll for a while.
By itself it's pretty harsh, and trippy because of the nicotine. I prefer it mixed with Cannabis and/or regular tobacco.
They need nutrients, lots of nutrients (epsom salt works like magic). And loose, sandy soil or the initial roots won't go anywhere.