Right now most companies (in the .NET world) just run on C# and no one tries anything new except when it arrives in C# (and even then its a struggle - even though the situation has improved a lot in recent years). A mixed model would also open other scenarios.
The mixed compilation is something that current web tech (using bundlers) has in advance. I can do crazy things and end up with the best (optimized) output using a common denominator.
On the F# track I fully agree - its a wonderful language that more people should try out.