I love playing around in Adobe Illustrator and so built my resumes in there. I spent DAYS and WEEKS crafting what I thought were a beautiful, icon rich, intuitive, apple-of-my-eye resumes. 250+ applications later the only time I ever got any response was from one or two small operations where it was a human manually reviewing submissions.
Turns out HR/recruiting suites that companies use aren't so hot on parsing, classifying, and tagging image based PDF resumes. Haha, who knew, right?
Finally a friend turned me on to LaTex and I had GREAT success with that. This made a ton of sense: what could be more machine readable than something built out using markup elements, tags, and IDs that explicitly do all that classifying work for the programs already.
So yeah, huge take-away: when your site constructs the resume if you're using HTML and then converting out to PDF (what we did on PortHub) make sure your HTML is verbose and explicit, even if it doesn't get displayed "on page".