I actually work faster using a [touchpad + keyboard] vs [mouse + keyboard]. The trick is placement. The touchpad needs to be right below the keyboard (like a macbook layout) so you can switch faster between typing and moving the cursor as opposed to using a mouse. If your OS / trackpad supports gestures, that increases speed of use as well.

For comfort, imo the whole thing needs to be lower, closer to your legs. If you're using a standing position instead of sitting, just change the position to closer to your thighs.