I’ve found every iPhone since the original 3.5” form factor too hard to use with one hand. I simply can’t reach all corners one-handed with anything larger.

I’ve been out of luck since the iPhone 4, so I often go for the largest. Might as well get the best camera and battery life.

I type with two thumbs on a phone because I type with two hands on a keyboard. In fact, one hand is tied up on a computer - on a mouse - more often than I can't use one with my phone. It's an acceptable tradeoff.

I’m on the beach right now, comfortably reading and replying to this thread with one hand on my SE. The other is shielding my eyes from the sunset.