That said, you've specifically mentioned infrastructure, and I don't think an infrastructure company would be possible in the YC model. It would take a vast amount of money to start a new hosting provider or cloud provider, if you aren't building on existing infrastructure (which a few YC companies have done, building on EC2 and other cloud provider products, including recently acquired Heroku and Cloudkick). YC invests a few thousand dollars. Building infrastructure costs millions of dollars. Building software is what YC companies do, and the best place to build most software today is on the web.
This should be a solid example that not everyone in YC is creating just a webapp that you can thrown onto a few EC2 instances in under 10 minutes.