Working at home, the existential dread and feeling of meaninglessness in my tasks increased with remote work for a time, given my separation from the distractions of workplace politics, drama, etc. that pervaded office life.
It is hard to make connections with coworkers, and it is so important to build a social life outside of work if you do not have one.
I find I work less hours in front of the computer, accomplish more, and have to spend more time "screwing off" to fill in that void of losing office banter, work lunches with coworkers, etc.