You can make a UI feel responsive even if the underlying system is not performant.
Let's say you have a client app with checkbox that toggles some boolean variable that communicates with a server. If you're on a 3g connection in an ambulance, it might take a few seconds to send that request to the server and get a response back.
An unresponsive UI would sit there and make you wait for the request/response to complete. You click the checkbox, then nothing happens, then suddenly, some time later, the checkbox is checked and the page refreshes, or a state change happens. It's jarring and weird. A responsive UI would update the state of the app based on the user's actions even if the request hasn't completed yet.
Tightly related to this the concept of optimistic UIs - the UI acts optimistically and updates the state of the app under the assumption that server-backed state changes will work. The iPhone's messages app sending messages is the prototypical optimistic UI interaction. You send a message, the blue / green speech bubble shows up on your messages app while the message is in flight. If it succeeds, nothing changes and you're none the wiser. If it fails, you get an option to delete the message or resend.