I am more motivated to eat healthier, exercise, and so on when I smoke regularly. I spent most of my 20's sober and the opposite in my 30's and overall, my experience in my 30's was much better. I remember about as much either way - at least in the long term. I also learned a second language while mostly stoned.
Overall, I'm much more motivated.
And I'll state that overall, my life is full of wasted time. I don't have children nor much responsibility, really, and I'm over 40. I'm happy, though, and that isn't just the beer talking.
Edit: I can go either with or without and have taken semi-regular breaks from time to time. I'm mostly at weekends now, but that's mostly to save money rather than life stuff.