For those saying they have to use Manual because of unevenly lit subjects or background light: I use a combo of spot metering + lock exposure toggle.

I can then recompose and keep shooting. No need to dial my SS or ISO manually.

The only time I play with shutter speed is if I want to introduce motion blur or freeze action.

Or when doing night photography on a tripod, I don’t want the camera raising the ISO because it’s trying to compensate for motion blur that doesn’t exist.