It's been a few years since I used Duplicity, and while I liked it, I prefer the Unixy one-thing-well approach of composing several smaller tools to achieve what I need.

The big thing I'm missing from Duplicity are incremental backups, which is not a strong requirement for my use case as bandwidth is cheap and I can delete the oldest N backups to free up space.

But I gain a lot from using a combination of tools: I can easily replace each component, and easily improve my workflow by adding more components, such as deduplication or incremental backups if needed.

Pretty much, and it stores additional indexes so it can do incremental backups. It supports many different storage targets, including S3, which I use.