Yes, definitely. And I'd assume that questioning "the meaning of it all" is something most people will do at some point. In particular, those who tend to think critically and independently about other questions, which I'm also assuming is a common trait of HN readers.

To me, the process was the following:

1. Realizing that society has created many layers of "fabricated" meaning (thinking of things like a successful career, owning a big house, an expensive car, being the best player in the soccer team, etc). I think those will quickly feel superfluous and the fact they are fabricated becomes apparent. They are in fact meaningless.

2. Understand that behind all that fantasy, we're still rather simple (social) animals. And coming to terms with that, helped me find meaning in basic things I'm hard-wired to enjoy: like nurturing the relationships with the ones I love, challenging myself in some sort of dimension (eg. sports, learning), being a positive influence for the younger generation, etc.

All in all, I think that questions makes you cut-through the bullshit society has fabricated over the years and go back to the core of what exactly makes you feel well. What makes you feel well, even if it's hard, is what you're supposed to do IMO.