The biggest threat the vast majority of people face is getting one of their accounts taken over because they re-use credentials and some site, somewhere, got their account db compromised and now those credentials are on a list. Any account that has 2FA, even ones that use "weak" 2FA like SMS, will be immune to being broken into. These drive-by people won't be breaking into your 1pass account to recover your 2FA secret either--that is too much work. They'll just move on all the accounts that don't have 2FA enabled.
(huge asterisk: what I said is only true for drive-by attacks where some bot is burning through a list of a million accounts to try. If somebody is specifically trying to attack you and your accounts... you've got bigger problems to worry about than simply having SMS-enabled 2FA or saving your 2FA keys in a password manager.)