Hmm, it never seems to open a window from that, though it remains responsive. (I can still open other files.)
Good old gedit can read the 450MB file handily, after a few seconds delay.
Aquamacs (Aqua emacs) asks me if I'm sure I want to open the file, then when I press Ok, it tells me it's too large to open a few seconds later.
If you just want to open a very large file with a GUI text editor, just continue to use your editor of choice, then download gedit for the very large files. It's small, respectably multi-platform, and free in both senses.
EDIT: Downmodded for reporting facts! Nice one, HN!