Yep, the touch screen in my car cracked recently and the AC got stuck on a very low setting and was constantly blowing out cold air - there was no way to adjust it without using the screen.
It is not only the single point of failure that is annoying but the fact that to control the AC you need to use the touch screen in AC mode which mean switching from GPS mode or radio mode etc. Very distracting when driving.
Car designers: Please give us more knobs!