If you're spending $1,000, what is 20 minutes setting up lighthouses? As far as I'm concerned, it barely even factors into the equation.
If you move your desktop PC around often, I can see why the Index or Rift S would be a non-optimal choice. I don't think this describes most people.
Edit: just noticed you said Rift S, maybe you meant the Rift? The Rift S doesn't use sensors, so moving it to another room just requires re-calibration in the new room, I believe.
Repeating setup if moving, and the sensors getting moved - from my experience it depends how much space you have available and how fully you have to utilize this space for VR. If available space is large enough, then I notice that it doesn't matter much if the boundaries get moved slightly, if I keep enough buffer between virtual boundaries and physical objects.