I disagree with leaping into the abyss because it's likely to be overwhelming and counterproductive in this context.
Change one aspect of your life at a time and see what happens. Move houses, change jobs, change social circles. Sit back and observe. It ties in with trying something different but also makes it more manageable instead of attempting to do everything at once. I think people have different tolerances for the amount of change they can adapt to.
I second the comment on the corporate machine making you unproductive and making you feel lazy. Corporations are large machines with huge overhead because the rules are designed for average employees. On the whole, stuff gets done, but at the individual level it minimizes upside and downside. Unless you have a talent or discipline for office politics, it isn't an attractive option. I would guess that the majority of HN readers would not enjoy that environment.
The quarter-life crisis and the early 21st century syndrome is prevalent amongst 20-30 yr olds. Societies are undergoing major change and it is fascinating to see how we will respond to the choices presented to us. Now that companies can be built with 2-3 people, it doesn't just allow for ycombinator to succeed, it forces young programmers to assess whether a forty year career path is the obvious choice. Personally, I think the life and career goals of earlier generations is not applicable any more but are still being passed down and unintentionally causing cognitive dissonance.