I upgraded a VMWare ESXi server hosting FreeNAS from a consumer motherboard with an Intel Core i7 3930K and it was completely painless.
[0]: https://www.asrockrack.com/general/productdetail.asp?Model=E...
My current HP home-server has been with me for ~10years
I've been seeing people try to make power architecture (ibm) servers a thing for 12+ years now, it never happens, because ordinary developers can't afford them. Compared to what you can put under your desk for a thousand bucks based on any Intel or amd, amd64 architecture system .
Or this? https://www.raptorcs.com/content/TL2B01/intro.html
$2700 and probably is outperformed by a $150 ryzen cpu on a $110 motherboard.
Except that it won't have open firmware on a CPU hardly anyone targets. Whatever you build will probably be vulnerable. Unless you're running OpenBSD or something.
In case you are curious to see benchmarks.
AM4 boards have similar verbiage.
They do not mention unregistered DIMMs being supported.
Obviously EPYC has a place but for the home usecase you could use a Ryzen as a substitution for Intel Xeons because of the baseline features of Ryzen.
Threadripper has 64 lanes, though, which is definitely a lot.
The future is more likely ARM- I know a few companies are experimenting with moving their internal servers to ARM, and AWS started offering that platform a few months ago.
But I'm not sure how long this takes, people have also been wrongly predicting the death of x86 since the 90s.