I've been leaning back towards firefox recently due to how chrome handles large number of tabs: poorly. It'll squeeze them down to the point that they wont even show the favicon, making finding an open page annoying - compared to firefox, which has a minimum tab length, and scrolls the tab bar if it grows too large to fit.

The rest might be a personal prefference, but I rarely use the mouse to close tabs anyway, ctrl+w is faster, and I can hit that as many times as I want without moving the cursor anywhere. I also preffer the / and ' shortcuts firefox has.