I wrote a lot of TypeScript just using Express, and it pretty much always ended up looking kind of like this.

Today, though, I think this is reinventing the wheel for little benefit. I've moved my own projects to NestJS (https://nestjs.com/) and have found myself paying a lot more attention to logic and application behavior rather than structuring code around a too-thin web server.

NestJS uses Express or Fastify under the hood--because both are great web servers!--but serves to make life a lot more pleasant when using them. The way it strongly encourages the decoupling of application logic (services) and the serving of data to clients (controllers) is a good one and, to me, does a much better job of creating an "enterprise NodeJS and TypeScript" environment than rolling one's own.