Personally, I'd like to see him start a company that would invent a mobile phone battery that lasts for a month and can power an RC aircraft to fly all the way around the world.
I also worry about the overall risklessness of what he's doing. He's pledged all of his money, so who can criticize it? For most people it's beyond reproach just because of the stated goals.
When Gates dropped out of Harvard he was doing something that a lot of people thought was stupid. That's how big ideas are. I'd like to see him doing something that might actually result in people mocking him for having lost his fortune on a bad idea.