E.g. how would the major organised religions cope with the revelation (pun intended) that there was life that originated off of Earth/outside of the garden of eden?
For a lot of people who take religion seriously, I feel like this could be a major upset. It might not affect "day to day life" in terms of the lights staying on and there being food on the shelves, but there could be a significant personal impact on a lot of people which may lead to a lot of things like depression/substance-abuse/suicides/general-"fuck it, its the end end of world, I am going to <x>"-sentiment/etc that will have knock-on effects (e.g. not turning up for work, abandoning family/responsibilities, running away to live as a hermit in the woods, gun hoarding etc)