To try and summarize without speaking too much for projects that I'm not intimately familiar with, Wormhole takes the approach of automating the configuration of WireGuard to create a full mesh encrypted network.
Other approaches take a much more comprehensive approach, of trying to solve key signing, identity, revocation, offload to the kernel and intercept via sidecars (using ebpf), etc. These tools come with many features and an inherent complexity, where I believe there is room for a simpler tool that is easier to use and troubleshoot.