In hindsight, we can see mistakes in terms of specific design and technical decisions. But I don't think those are the biggest lessons from the disaster. We will continue making such mistakes, since technical misjudgement itself will always happen. I think Challenger Launch Decision's main point, that the organizational structure and culture have large impact on individual decision making is the lasting lesson. The book's closing sentence is excellent:
"The lingering uncertainty in the social control of risky technology is how to control the institutional forces that generate competition and scarcity and the powerful leaders who, in response, establish goals and allocate resources, using and abusing high-risk technical systems".