That is not to say we should not continue to try to understand the world around us. Only that logic dictates that we proceed with humility.
Definitely. I wholeheartedly subscribe to this view (https://en.wikipedia.org/wiki/All_models_are_wrong). The thinking mind will always be confined to models. The way I see it, the questions posed here are an expected wall one will eventually hit when the mind attempts to explain something that is fundamentally inexplicable - i.e the nature of existence.
My current intuition is that the hard philosophical questions posed by probing deep into what matter essentially is are deeply linked to the hard problem of consciousness.
I'll make an even bolder claim, which is that both of these questions arise from a misunderstanding of what consciousness actually is and that no less than a Copernican revolution in understanding its role is what's needed to put them to rest.
Of course, that won't be the end of physics, as the mystery is endless - but it might be the start of a deeper humility and appreciation of that mystery.
Luckily the subjective sciences are already highly developed, just look at Kabbalah. You can read a thousand pages of it and you still won't understand a single word!