We've taken a layered approach to designing Fluent: what we're announcing today is the 1.0 of the syntax and file format specification. The implementations are still maturing towards 1.0 quality, but let me quickly describe what our current thinking is.
For JavaScript, we're working on low-level library which implements a parser of Fluent files, and offers an agnostic API for formatting translations. On top of it we hope to see an ecosystem of glue-code libraries, or bindings, each satisfying the needs of a different use-case or framework.
I've been working on one such binding library called fluent-react. It's still in its 0.x days, but it's already used in a number of Mozilla projects (e.g. in Firefox DevTools). In fluent-react translations can contain limited markup. During rendering, the markup is sanitized and then matched against props defined by the developer in the source code, in a way that overlays the translation onto the source's structure. Hence, this feature is called Overlays. See https://github.com/projectfluent/fluent.js/wiki/React-Overla....
Here's how you could re-implement your example using fluent-react. Note that the <a>'s href is only defined in the prop to the Localized component.
<Localized
id="confirm"
$clickCount={7}
a={<a href="..."></a>}
>
{"Please <a>click here {$clickCount ->
[one] 1 time
*[other] {$clickCount} times
}</a> to confirm."}
</Localized>
I'd love to get more feedback on ideas in fluent-react. Please feel free to reach out if you have more questions!