I would be wary of someone with only 2 years experience and a 5 year absence. In short, you need some way to prove your technical capability to counter that.

Open source work, blogs etc are commonly suggested as easy ways to do this. Don't worry about a big portfolio and power brand name, just being able to send a link with your application and say here's an interesting bit of code I wrote will put you way ahead of most applications. For example I recently wrote around 1,000 lines of code to do some experiments with Node.js, Socket.IO and Coffee Script. That would be perfect.

It also gives you a great talking point for when you do get an interview.