I do. I remember posting this to the mailing list. I don't have an example calculating enrichments though. We simply group by read and divide using the frequencies and then plot one enrichment vs another. This way we can see how one sequence enriches between conditions. There's more to it than that but this will produce a plot similar to the one in the attachment in the thread linked below.

https://groups.google.com/a/continuum.io/forum/m/#!msg/bokeh...

Edit: here's a link to the plot I refer to: https://10826817673355204906.googlegroups.com/attach/e6e58ad...