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It was also meant to be the name of a major ElementaryOS release IIRC.

The River Thames through Oxford is locally known as the Isis, so there are dozens of businesses called things like the 'Isis Guest House'. Many of them have rebranded.

Isis is also the name of an ancient Egyptian goddess.

I imagine it's a recurring problem. There were probably some people named Hitler in the 40's that faced the same problem. I imagine Adolf too, to a much lesser degree.