Of course, no post like this is complete without OISC:

https://en.wikipedia.org/wiki/One_instruction_set_computer

(Then, there's my contribution: NISC -- the Null Instruction Set Computer! It's a revolutionary architecture, in that die sizes and TDP can be scaled down, seemingly arbitrarily, with no loss in functionality. In fact, NISC can transcend the solid state entirely, and be implemented directly on the quantum foam of the vacuum!

Another benefit: NISC machines are entirely immune to all buffer overflow and use after free exploits! In fact, they are free of all exploits, whatsoever!)