It's much harder to see it all at once, so you end up just treating it as a free floating space to organize things, much like a real desktop (do you layer all your items our to maximize used space on physical desks as well?).
While not working, I'll spend most the time with a browser window utilizing slightly more than a quarter of the screen towards the bottom left, and not much else, maybe some small transient file folder windows.
While working, I keep the browser, but I add a few large terminal windows. Usually one mostly upper center, bottom right, but the upper center one might overlap other windows slightly (because why not? I can make it large without slight overlap and very little loss of passive usefulness of other windows).
It's fairly liberating. I now view tight control and maximizing utilized space as a response to lack of space, which is no longer my problem. In the beginning, I wasn't sure if I was going to regret this, and was looking for utilities to set screen areas that I could maximize to, or save presets for certain applications. Then I just let go, and it's been wonderful ever since.
If you're interested, I still recommend the TV I got (or something better maybe now). It's got low input lag (~13ms) and does 60hz at 4k, all for about $500 at Amazon[1] (I think it was ~$400 when I got it on sale).
1: https://www.amazon.com/VIZIO-D40-D1-Class-Array-Smart/dp/B01...