I'm making one going in almost the polar opposite direction to this. I 8-bit avr based with asm (and C,pascal and anything else the avr ecosystem supports)
It's slow going (current work in progress in-broswer emulator+assembler at http://fingswotidun.com/avr/AvrAsm/Testbed/ ) Still have to make a website for sharing cartridge images.
Also this caught my eye in the linked article.
"TypeScript is compiled directly to machine code - there is no interpreter or JIT-compiler involved." There's a Typescript to native compiler about? Where?