I'm trying to answer your question, and it's hard.
Really, though, you have to use all the leverage points (or a subset of them). The point of the list was not: Which of these will achieve the desired external behavior the best? The point is: Which of these will actually alter the system itself so that it doesn't regress when removed?
Prohibition didn't eliminate alcohol consumption, it only changed how it was acquired. It made use of a number of the leverage points but fundamentally the US was still a nation of alcohol consumers. Tobacco use has been reduced in the US, but not eliminated, through education and taxes on tobacco products. Education (at least for my generation, now mid-30s) seems to have had a huge impact and actually changed the way it's viewed (so it achieved a paradigm shift).
To change the system (and maybe the paradigm) you'll have to use several of them. Raise taxes on the product (#12). Increase information flow about the consequences of tobacco use (#6). Reduce the positive feedback loop of using it by making it "uncool" (#7). Introduce alternatives that provide the chemical fix (nicotine) without (as much of?) the health consequences via patches and gum (#4).
To directly attack the paradigm itself, you have to use education and propaganda. Which will have varying effectiveness. For points #1 and #2 to be useful, you either have to be an individual with an open mind and the ability to introspect, or a learning organization. That latter part gets harder and harder the larger the organization becomes. A small team can alter its course more easily than a small business, which is more adaptable than IBM or the US population.