Naltrexone and Bupropion. It doesn't make the other parts of losing weight unnecessary, but it does make it easier to handle cravings. I don't care that I'm getting some willpower in a bottle - I'd simply like to weigh less.

Two years ago, I was ~300. I had been constantly gaining weight since I started taking Seroquel. I also had ankle surgery (unrelated to my weight), and was completely bedridden for 6 months, then in PT for another 5. After that, my doctor put me on those two medications.

I still had to be careful about what I ate, but the occasional snack was occasional; I could eat something bad for me once a week and not lost much progress. After a while the exercise was more pleasant, too.

I hit 220 a few months ago. When I switched jobs and stopped taking the two medications (doctor and I just wanted to see if the weight would stay off without them), my weight jumped back up to 250, but stabilized there. A good bit less than the 300. I started taking the two medications again, and now I'm losing it again.