I wish we had the kind of concerted effort that the copyright lobby is able to launch, but focused on issues that reduce the net benefit of these platform more than copyright infringement: hate speech or intentional misinformation.
I can imagine someone writing a TOR-based eMule client or something along those lines but it won't be anywhere near as common as it was back in the days; ease of use has always been an important factor and today we actually do have commercial alternatives in place this time.
As I see it, the main impact will be for social networks and other sites that allow user uploads. There's an actual chance the people behind the law simply don't understand that what they're asking isn't possible, and that many politicians think we just need to solve this with blockchains and machine learning (because that's apparently how to fix everything nowadays). In the real world, however, I really see no way to comply with that law without mass-monitoring and very far-reaching automatic censorship of uploaded content.
Social networks.