I believe what they try to achieve is beyond what we currently have. And if Mises was born in this age, he would've probably go to the biology level or even deeper to start his work. The tooling and data to connect the dots in his mind was simply not there. To me, he wanted something that is not approximate. For those purposes, what you mentioned might be the best tools one can have at starting stage. I think some work in micro-economics has something similar to Mises'. They can work on simulations now to have fact-based and measurable discoveries. In the end, most likely what human can do is limited to the tooling, not the understanding and educated imagination.