Historically, nation-states have been mostly defined by culture, which is defined by language, which was mostly defined by communication speed, which was mostly defined by actual transportation speed. That's not an element anymore because all culture can be everywhere at any time. A new approach is required.
Since then, most of the attention has been on tribulations resulting from the common currency, 2008, and migrations, so there is a general unwillingness to rock more boats.
I won't argue the fact that Cyrus was enormously influential to the course of fertile crescent civilizations. That said, really he was just one of the first Fertile Crescent leaders to see not only the weaknesses of the city-state, but the means by which to exploit those weaknesses. (It's just that what he did to exploit those weaknesses was so radically orthogonal to the way things were done at the time that even today we're still calling the guy Cyrus the Great.)
Once the Nation-State idea was out of the bag, city-states just couldn't compete. Even the Greek city states fell to Macedon because by the end of the Theban hegemony, they were all so weak that even Macedon, effectively a baby nation-state at the time, was able to take them out. City-states wouldn't be able to compete today either. You'd always have to have some great power around to back them. Even Federations of city-states have faired poorly historically.
It's like continuing to rely on bronze swords once people got the hang of making iron ones. It no longer mattered all of the reasons that bronze was better for you, because iron was better when it counted. The cat was out of the bag, you could try to put it back in the bag, but everyone's already seen it.
In a world where everyone sorta-speaks English and the power is in know-how and transnational market access, it counts very little that you can mobilise this or that amount of tanks. It counts even less if those tanks are coordinated at a higher level anyway.
The other thing is that a place like Singapore is exceptional. It’s a strategic chokepoont established by a colonial power.
It is sometimes used as one, thought it is also sometimes argued that the advantages of city-states are offset by problems (among others, international instability) unless the city-states are relatively rare and economically engaged with (and buffered from each other by) larger polities.