Just because a candidate fails or falls short in one area doesn't mean they are cut, but it's a pretty large red flag if a candidate purports to know something, both on their resume and in person, yet can't answer some seemingly basic questions. If you state on your resume that you architected and implemented a system end to end, yet can't whiteboard the result and explain bottlenecks or failure conditions, I absolutely will assume you stretched the truth a bit. And if the candidate feels the need to do that to get the job, what will it be like to work with them? Could you trust their estimates? Would you be able to back them if something they delivered fails and you trusted them as a senior to deliver?
I ask follow-ups. I give hints. Honestly I'm dismayed at the skillset of purported "seniors" and "architects", and that's interviewing for small companies up to one of the FAANGs.