(1) Clasp interoperates with C++ - C++ libraries like graphics and physics engines can be easily exposed within Clasp Common Lisp. (See https://github.com/clasp-developers/demo-expose-bullet-physi...)
(2) Clasp uses llvm as the backend - it generates llvm-ir from Common Lisp code and uses link time optimization to link C++ and Common Lisp generated llvm-ir.
(3) Clasp uses the Memory Pool System garbage collector, which can be configured to minimize GC pause times to a programmer-defined level.
(4) Clasp generates debug info and can be profiled with standard tools like dtrace and C++ functions, Common Lisp functions and GC functions are all profiled against each other.
I'm a professor of Chemistry at Temple University - I'm developing Clasp to design molecules and materials - but it could be applied to a lot of other problems.
Caveat: Clasp is not yet as performant as Steel Bank Common Lisp, but it uses the open source and highly configurable Cleavir compiler developed by Robert Strandh and we have incorporated inlining and are currently incorporating type inference.
If you want to see a little bit more - I have a 25 min talk up on youtube that I presented a couple of weeks ago at the 2018 llvm developers meeting (https://www.youtube.com/watch?v=mbdXeRBbgDM&feature=youtu.be)