Is alzheimers a prion disease, or maybe just Prions are involved?
https://www.newscientist.com/article/2151909-alzheimers-may-...
So while wiring together two bloodstreams is a bit extreme, and likely to result in most things being transmissible, there's nonzero evidence that you can have a bad day from a blood transfusion.
Regardless, it's unrelated to prions.